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Doxylamine, a sleep aid and antihistamine, is an active ingredient in a number of over-the-counter medications, including NyQuil. In this model, mice are forced to swim in a restricted space from which there is no escape. It has been suggested that the centrally active 1 and 2 adrenergic agonists produce antidepressant-like effects in several behavioral tests, suggesting that these receptors may be involved in the mediation of the effects of antidepressant drugS Down-regulation of -receptors was proposed as the neuronal target for the effects of some antidepressantS Duncan, reported that imipramine, a common antidepressant drug, induces down-regulation of beta adrenergic receptors.
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